Faculty Research
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Richard Henker, PhD, RN, FAAN
| Department: |
Acute & Tertiary Care |
| Location: |
336 Victoria Building |
| Email: |
rhe001@pitt.edu |
| Phone: |
412-624-3816 |
Keywords
- Anesthesia
- Traumatic Brain Injury
Current Funded Research
Henker, R
09/01/05-08/31/09
AANA
The Association Between Mu-Receptor Genotypes and Postoperative Pain Response
Anesthesia providers caring for patients undergoing surgical procedures recognize the inconsistency in response to opioids during the perioperative period. This inconsistency has been attributed to factors such as individual genetic difference. Identification of these genetic differences prior to surgical intervention may help in determining safer more effective opioid requirements for patients. The purpose of this study is to explore the relationship of mu receptor genotype and postoperative pain response.
The purpose of this study is to explore the relationship of mu receptor genotype with postoperative pain response and the amount of opioid administered. The primary specific aims of this pilot study are to: 1) estimate the frequency of polymorphisms of mu receptors in subjects receiving general anesthesia for a lower extremity single orthopedic surgical procedure involving peri-articular or shaft injury repair; and 2) explore the effect of genetic variation in mu opioid receptor on the amount of opioid administered and postoperative pain response in subjects receiving general anesthesia for a lower extremity single orthopedic surgical procedure involving peri-articular or shaft injury repair. Secondary aims of the study are to explore the interaction of gender and mu receptor genotype on pain response and to explore the role of the amount of opioid administered as a possible mediating effect on the relationship between mu opioid receptor subtype polymorphisms and pain response.
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