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Henker, R.
09/01/05 – 08/31/07
AANAF
The Association Between Mu-Receptor
Genotypes and
Postoperative Pain Response
Anesthesia providers caring for patients
undergoing surgical procedures recognize the inconsistency in
response to opioids during the perioperative period. This
inconsistency has been attributed to factors such as individual
genetic difference. Identification of these genetic differences
prior to surgical intervention may help in determining safer
more effective opioid requirements for patients. The purpose of
this study is to explore the relationship of mu receptor
genotype and postoperative pain response.
The purpose of this study is to explore the
relationship of mu receptor genotype with postoperative pain
response and the amount of opioid administered. The primary
specific aims of this pilot study are to: 1) estimate the
frequency of polymorphisms of mu receptors in subjects receiving
general anesthesia for a lower extremity single orthopedic
surgical procedure involving peri-articular or shaft injury
repair; and 2) explore the effect of genetic variation in mu
opioid receptor on the amount of opioid administered and
postoperative pain response in subjects receiving general
anesthesia for a lower extremity single orthopedic surgical
procedure involving peri-articular or shaft injury repair.
Secondary aims of the study are to explore the interaction of
gender and mu receptor genotype on pain response and to explore
the role of the amount of opioid administered as a possible
mediating effect on the relationship between mu opioid receptor
subtype polymorphisms and pain response.
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